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Hospital to get first dedicated 3D tissue-printing facility

Hospital to get first dedicated 3D tissue-printing facility. Science & Technology World

You still can't get a 3D-printed liver transplant made from your own cells, but an Australian hospital is trying to push the tech into the mainstream. The Queensland University of Technology (QUT) in Brisbane is building a dedicated "biofabrication" space where doctors and researchers can develop tech to model and print cartilage, bone and other human tissue. "It will be the first time a biomanufacturing institute will be co-located with a high-level hospital," said Australian Minister of Health Cameron Dick.

The facility will occupy two floors of the hospital and use state of the art tissue manufacturing tech in surgery procedures. "Our vision for healthcare is that the biofabrication institute will pave the way for 3D printers to sit in operating theaters, ready to print tissue as needed, in our hospitals of the future," Dick said.

It's still early days for 3D tissue and medical implant printing, but QUT is one of the facilities pushing the limits, along with Wake Forest, Harvard University and others. Researchers have grown (but not 3D printed) bladders from patients' own cells and successfully transplanted them, and attached human ear prostheses made (in part) from living tissue. Building more complex organs (like highly sought kidneys) has proven a challenge, however, because it's hard to supply blood and keep them alive for longer than a few months.

Hospital to get first dedicated 3D tissue-printing facility. Science & Technology World

Biofabrication shows the most promise for less complex body parts likecartilage and bone. "A lot of the implants we are developing, we can implant into a patient and as the tissue grows back, it is not rejected, the scaffold will reabsorb over time and the tissue will grow even more and eventually the implant is gone," says Associate Professor Mia Woodruff. "We don't always have to use metallic implants any more, we can develop really high-spec composite materials that dissolve as the tissue heals."

However, the big prize would be the ability to 3D print a rejection-proof organ built from a patients' own cells. "We are not going to be able to 3D print an organ tomorrow but what we are able to do is bring together the researchers, the clinicians, the patients, the engineers, the intellect and industry partners to be able for us to develop new technology to the level where it can be translated into the clinic," Woodruff says.

3D-printed titanium hips will last longer with less pain

3D-printed titanium hips will last longer with less pain. Science & Technology World Website

A mechanical engineering professor at McGill University has designed a new 3D-printed titanium hip replacement that will not only take the place of your aging femur, but can also fool the living bone into working harder for longer. According to the University, Damiano Pasini's femoral stem is printed with a "hollowed-out tetrahedra" design that resembles the porousness of actual bone, rather than dense materials of older hip replacements.

The biggest issue with existing hip replacements is that they are actually too rigid and tend to take some of the stress off of living bone, which causes it to weaken and deteriorate. Over time, this leads to painful joints and eventually the need for a second hip replacement -- which can be difficult if there's no living bone left for the artificial joint to graft on to. In much the same way that 3D-printed "dough" can encourage bones to heal, Pasini's design helps the body heal itself.

"So because the implant loosely mimics the cellular structure of the porous part of the surrounding femur, it can 'trick' the living bone into keeping on working and staying alive," Pasini explained. "This means that our implant avoids many of the problems associated with those in current use."

While the new hip replacements aren't the most dramatic 3D-printed bone replacements we've seen, they will work with existing hip replacement techniques so surgeons won't need to undergo any additional training when they start putting these to use in the next three to five years. And, assuming Pasini's research holds true, they'll also lead to fewer complications in the long run.

New System Converts MRI Scans into 3D-Printed Heart Models for Surgical Planning

New System Converts MRI Scans into 3D-Printed Heart Models for Surgical Planning. Science & Technology World Website

 The models could provide a more intuitive way for surgeons to assess and prepare for the anatomical idiosyncrasies of individual patients. “Our collaborators are convinced that this will make a difference,” says Polina Golland, a professor of electrical engineering and computer science at MIT, who led the project. “The phrase I heard is that ‘surgeons see with their hands,’ that the perception is in the touch.”

This fall, seven cardiac surgeons at Boston Children’s Hospital will participate in a study intended to evaluate the models’ usefulness.

Golland and her colleagues will describe their new system at the International Conference on Medical Image Computing and Computer Assisted Intervention in October. Danielle Pace, an MIT graduate student in electrical engineering and computer science, is first author on the paper and spearheaded the development of the software that analyzes the MRI scans. Medhi Moghari, a physicist at Boston Children’s Hospital, developed new procedures that increase the precision of MRI scans tenfold, and Andrew Powell, a cardiologist at the hospital, leads the project’s clinical work.

The work was funded by both Boston Children’s Hospital and by Harvard Catalyst, a consortium aimed at rapidly moving scientific innovation into the clinic.

MRI data consist of a series of cross sections of a three-dimensional object. Like a black-and-white photograph, each cross section has regions of dark and light, and the boundaries between those regions may indicate the edges of anatomical structures. Then again, they may not.

Determining the boundaries between distinct objects in an image is one of the central problems in computer vision, known as “image segmentation.” But general-purpose image-segmentation algorithms aren’t reliable enough to produce the very precise models that surgical planning requires.

Human factors

Typically, the way to make an image-segmentation algorithm more precise is to augment it with a generic model of the object to be segmented. Human hearts, for instance, have chambers and blood vessels that are usually in roughly the same places relative to each other. That anatomical consistency could give a segmentation algorithm a way to weed out improbable conclusions about object boundaries.

The problem with that approach is that many of the cardiac patients at Boston Children’s Hospital require surgery precisely because the anatomy of their hearts is irregular. Inferences from a generic model could obscure the very features that matter most to the surgeon.

In the past, researchers have produced printable models of the heart by manually indicating boundaries in MRI scans. But with the 200 or so cross sections in one of Moghari’s high-precision scans, that process can take eight to 10 hours.

“They want to bring the kids in for scanning and spend probably a day or two doing planning of how exactly they’re going to operate,” Golland says. “If it takes another day just to process the images, it becomes unwieldy.”

Pace and Golland’s solution was to ask a human expert to identify boundaries in a few of the cross sections and allow algorithms to take over from there. Their strongest results came when they asked the expert to segment only a small patch —one-ninth of the total area — of each cross section.

In that case, segmenting just 14 patches and letting the algorithm infer the rest yielded 90 percent agreement with expert segmentation of the entire collection of 200 cross sections. Human segmentation of just three patches yielded 80 percent agreement.

“I think that if somebody told me that I could segment the whole heart from eight slices out of 200, I would not have believed them,” Golland says. “It was a surprise to us.”

Together, human segmentation of sample patches and the algorithmic generation of a digital, 3-D heart model takes about an hour. The 3-D-printing process takes a couple of hours more.


Currently, the algorithm examines patches of unsegmented cross sections and looks for similar features in the nearest segmented cross sections. But Golland believes that its performance might be improved if it also examined patches that ran obliquely across several cross sections. This and other variations on the algorithm are the subject of ongoing research.

The clinical study in the fall will involve MRIs from 10 patients who have already received treatment at Boston Children’s Hospital. Each of seven surgeons will be given data on all 10 patients — some, probably, more than once. That data will include the raw MRI scans and, on a randomized basis, either a physical model or a computerized 3-D model, based, again at random, on either human segmentations or algorithmic segmentations.

Using that data, the surgeons will draw up surgical plans, which will be compared with documentation of the interventions that were performed on each of the patients. The hope is that the study will shed light on whether 3-D-printed physical models can actually improve surgical outcomes.

“Absolutely, a 3-D model would indeed help,” says Sitaram Emani, a cardiac surgeon at Boston Children’s Hospital who is not a co-author on the new paper. “We have used this type of model in a few patients, and in fact performed ‘virtual surgery’ on the heart to simulate real conditions. Doing this really helped with the real surgery in terms of reducing the amount of time spent examining the heart and performing the repair.”

“I think having this will also reduce the incidence of residual lesions — imperfections in repair — by allowing us to simulate and plan the size and shape of patches to be used,” Emani adds. “Ultimately, 3D-printed patches based upon the model will allow us to tailor prosthesis to patient.”

“Finally, having this immensely simplifies discussions with families, who find the anatomy confusing,” Emani says. “This gives them a better visual, and many patients and families have commented on how this empowers them to understand their condition better.”



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